The main symptomatic manifestations of Psoriasis, Eczema and Dermatitis (PED) involve excessive, uncontrolled growth of epidermal cells, complicated by secondary microbial infections.
Despite being referred to as distinct diseases, those conditions share an identical basic cellular physiopathology involving inordinate cell growth as a common factor.
Although the exact causes of PED are not yet clearly understood, PED diseases are considered to be mainly due to genetic factors, auto-immunity, immune-modulation, allergic reactions, stress, and other causes, but excessive and abnormal skin cell growth and the presence of different cytokine-secreting cells (neutrophil granulocytes, macrophages, lymphocytes,…) and cytokines at the site of infection, are the common features in all PED-affected skin lesions.
It’s been observed that PED lesions contain a very high concentration of multiple cytokines (EGF, KGF, TNF alpha, IL-6: interleukin-6), some of which are growth factors that continue stimulating cell proliferation, causing abnormal epidermal growth, formation of loosely attached epidermis, allowing microbial contamination, and resulting in the typical dermatological symptoms of PED.
Blocking the activity of growth factors responsible for excessive & uncontrolled cell growth and cleaning the lesion of contaminants is the only way to normalize skin cell growth and to provide symptomatic relief.
Hemorrhoids involve dilation of blood vessels, damage to the surrounding vascular structure, oedema and topical inflammation due to the presence of multiple pro-inflammatory cytokines (IL-4, IL-6, TNF-alpha) on the hemorrhoidal surface.
Hemorrhoids can be healed if:
1. Oedema is removed so that organs & tissues have a possibility to regress and resume their normal physiology;
2. Lesions are hydrated and cleaned of all contaminants, including any cytotoxic chemical (ex. antiseptics) and cellular debris;
3. Pro-inflammatory cytokines on the hemorrhoidal surface are neutralized.
Mast cells play a key role in topical allergic reactions. When an allergen comes in contact with the cellular mucosa, T&B cell activation produces IgE antibiodies that attach to the mast cells & trigger the release of histamines. This increases vascular permeability, mucus secretion, and consequently inflammation, oedema, irritation, sneezing, runny nose, itchy eyes, …
Histamine, in turn, leads to the production of multiple cytokines: anti-inflammatory to heal & pro-inflammatory to maintain the inflammation & the repair process. The key pro-inflammatory cytokines (proteins) involved are: IL-1, IL-6, IL-12, IL-17, IL-18, TNF-α.
Protecting the exposed surface so as to avoid allergen contact, and blocking histamine as well as the pro-inflammatory cytokines, should therefore provide instant relief.
Cleaning the lesion/mucosa surface, blocking inflammation through neutralization of pro-inflammatory cytokines, and preparing a healthy ground for the natural healing processes to take place.
PED: All the currently available cytokine-inhibiting drugs act solely on one of the factors implicated: for instance new drugs like adalimumab, infliximab and etarnercept block only TNF-α; kineret blocks IL-1; protopic inhibits IL-2; efalizumab antibodies bind only to LFA-1 antigen; and fusion protein alefacept only blocks CD2 receptors on T-cells. Systemic administration of these drugs also generates multiple and severe side effects. Since these drugs do not neutralize all the cell growth-stimulating cytokines, their therapeutic efficacy is extremely limited.
Hemorrhoids: Only symptomatic treatments are available.
Topical allergy: Antihistamines, corticosteroids, analgesics and saline solutions for nasal wash. These treatments target one of the symptomatic parameters but not the whole physio-pathology of topical allergic reactions.
Anti-Cytokine Approach :
As all cytokines and growth factors are proteins, we postulated that they could be neutralized by specific polymers. We employed big phenolic polymers with multiple-structure units having selective protein (cytokine) -binding properties due to their capacity to form strong hydrogen bonds with various proteins, and particularly cytokines.
VB-Gy or VB-HPC, to clean & to protect the lesions or mucosa surfaces :
Through its very strong osmotic activity, VB-Gy induces an instant exudation of hypotonic fluids across the affected surface, thus cleaning the lesion of the polymer-protein conjugates, as well as all contaminants present, including bacteria, thus acting as an instant, natural antiseptic, antimicrobial, and hydrating device.
These specific cytokine inhibitor polymers were incorporated into filmogen VB-Gy hypertonic solution or non-hypertonic VB-HPC film-forming solution to add anti-microbial and cleaning properties to the products.
Published Articles :
• Shrivastava R, Cucuat N, John GW. Effects of Alchemilla vulgaris and Glycerine on Epithelial and Myofibroblast Cell Growth and Cutaneous Lesion Healing in Rats. Phytotherapy Research 21, 369-373, 2007.
• Shrivastava R, Cucuat N, Shrivastava C, Rousse M. Multiple cytokine inhibition through specific procyanidin enriched plant extracts: Implications for the treatment of Psoriasis, Eczema & Dermatitis. Submitted for publication. J Dermatological Treatment. 2013.
• Shrivastava R, Rousse M, Dru L, et al. Recent Advances in the Use of Polymerics as Topical Protein Antagonists. Eur J Pharm Med Res, 2015; 2(5), 1627-1660. ISSN: 3294-3211.
The Following Medical Devices implement this completely new therapeutic approach conceived by VITRO-BIO Pharma, France:
VB-DERM to treat psoriasis, eczema & dermatitis: a topical multiple cytokine inhibitor and cell growth regulator, presented as a viscous solution for the treatment of Psoriasis, Eczema, and Dermatitis lesions (50ml tube).
Pileseptine: to reduce the oedema rapidly, stop inflammation and keep the hemorrhoidal surface clean & hydrated.
Allerspray: to provide instant symptomatic relief, to protect from allergen contact, and to treat pollution and hay fever -induced allergic reactions (rhinosinusitis).