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Cough spray

DRY & WET COUGH SPRAYS (Adult & Kids)

Physiopathology: Coughing is the sudden expulsion of air from the Upper respiratory tract (URT) to block the entry of contaminants in the lower RT & to avoid pulmonary infection. When the URT surface is damaged due to an infection (viral or bacterial), irritation or smoking, the throat mucosal cells die and produce cellular debris. Damaged mucosal surface creates a favorable ground for the growth of microorganisms leading to inflammation, liberation of cytokines (inflammatory proteins), leading to irritation, pain & coughing. In dry cough, the throat surface is dry with no phlegm or mucus & the throat mucosa is highly damaged. In wet cough, throat surface is mucoid, sticky containing many virus particles on an inflamed mucosa.

An Ideal treatment: Because cough is a multifactorial condition, simultaneously involving viral infection, cellular damage, strong bacterial growth, & topical inflammation, an effective treatment should act on all these factors at once, otherwise it can’t be effective. It should also be non-irritant, fast acting & safe.

Currently available treatments: All the currently available treatments are symptomatic a mono-target such as such as the expectorants (ipecacuanha), mucolytic (acetylcystine), antitussives (centrally acting such as opioids, codeines, morphine), non-opioids (such as anticholinergic benzonatate), anti-inflammatory, & antibiotics acting on one of the parameters involved in coughing. These are symptomatic drugs and have multiple side-effects such as addiction, nausea, drowsiness, headache, sedation. They don’t improve throat dryness, inflammation, virus load, and therefore they don’t allow natural healing to occur.

VITROBIO’s ANTI-COUGH APPROACH

Cleaning away the mucus & the contaminants, mechanically reducing/stopping local inflammation, irritation & pain, and the cough reflex:

After 20-years of R&D, VITROBIO discovered and patented a viscous liquid, 18 times more osmotically active than sea water yet NON-IRRITANT (VB-Gy – PCT/FR99/01340). For a prolonged activity, VB-Gy was rendered filmogen using specific plant polymers (PCT/EP2013/061835). When applied on the throat surface, this hypertonic film attracts hypotonic liquid & generates a strong outward liquid flow. Along with protecting the throat surface, the liquid flow drains away the bacteria, viruses & other contaminants thereby reducing the cough reflex. It also removes the inflammatory cytokines locally present to reduce /stop inflammation and pain. Simultaneously, continuous liquid flow dilutes & removes the mucus and keeps the throat surface hydrated. VB-Gy has 4 key functions: Protective + Antimicrobial + Cleaning + Soothing.

 

Clinical Efficacy:

A 14-day, randomized, placebo controlled, double blind, efficacy and safety study was conducted on 37 dry cough treated v/s 17 saline solution treated comparator patients for maximum 14-days. Cough related parameters were evaluated on days 1, 2, 3, 6, 9, 12, & 14. Compared to the comparator product, test product triggered an instant & strong reduction in mean scores of cough severity & frequency. A strong reduction in throat pain irritation, swelling, & redness along with a remarkable improvement in Leicester cough questionnaire was recorded. No drug-related undesired events were noticed.

Full trial published in J. Clinical Trials, Shrivastava et al., 2017, 7:4: DOI: 10.4172/2167-0870.1000318