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COUGHSPRAY: Effective Relief for dry and wet Cough


COUGHSPRAY from Vitrobio is a revolutionary 30ml throat spray designed to treat acute dry and wet cough. This unique formulation included a blend of glycerol, honey and tannin-rich plant extracts, ensuring a high-quality product that is both effective and safe for use.

COUGHSPRAY has demonstrated clinical efficacy by forming a protective film, regulating mucus adhesion, and hydrating the throat. Its osmotic action clears mucus in wet cough and soothes dryness in dry cough, reducing cough triggers for targeted relief

For Adults: Available in two formulas – Code CW and Code CDN

For Children: Available in two formulas – Code CE and Code CES


Clinical trial

Randomized, double-blind, placebo-controlled trial

Population

This product is intended for adult use

Indication

Used in adults for the treatment of acute dry and wet cough.


Claims

  • Significantly reduces the severity and frequency of coughs within the first few days of treatment. 
  • Rapidly relieves the pain, irritation, swelling and redness of the throat associated with dry coughs. 
  • Immediate action thanks to its hypertonic, filmogenic formula which mechanically cleanses the surface of the throat.
  • Helps reduce contact between irritants and the throat mucosa, thereby alleviating the cough reflex.
  • Soothes throat irritation and pain.
  • Reduces the need for antibiotics.
  • Improves the quality of life of patients. 
  • Clinically proven effective.


Mode of Action

 

The unique formulation of COUGHSPRAY targets throat irritation, and throat mucus accuumulation to deliver relief and soothing effects. Its mechanism of action operates through three key pathways:

Protective Barrier Effect: COUGHSPRAY forms a thin, protective film over the throat mucosa, regulating mucus adhesion in wet cough while shielding the irritated mucosa in dry cough. This barrier helps reduce throat discomfort and supports natural symptom relief

Osmotic and Cleaning Effect:  The product's high osmotic activity helps optimize mucus consistency in wet cough, facilitating natural clearance, while in dry cough, it maintains hydration, alleviating throat dryness and irritation.

Cellular Repair and Growth Effect: By creating a clean and hydrated biological surface, COUGHSPRAY immediately triggers cell growth and healing. This helps restore the integrity of the throat mucosa, further alleviating symptoms and promoting recovery.

  



Clinical Trial Results


The efficacy of COUGHSPRAY has been demonstrated in a randomized, double-blind, placebo-controlled trial over two weeks. The study included 54 patients, with 37 receiving the test product and 17 receiving the comparator. The results were impressive:

  • Antibiotics: The requirement for antibiotics was significantly reduced in the test group (10.81% of patients) compared to the placebo group (82.35%).
  • Severity: There was a 76% reduction in dry cough severity within 12 days.
  • Frequency: There was a 98% reduction in dry cough frequency within 14 days.
  • Throat Irritation: There was a 90% reduction in throat irritation within 12 days.
  • Throat Pain: There was a 99% reduction in throat pain within 14 days.

These results demonstrate the effectiveness of COUGHSPRAY in providing rapid and lasting relief from the symptoms of cough, while also reducing the need for antibiotics. No side effects were recorded, further attesting to the safety of the product.

COUGHSPRAY by Vitrobio represents a new era in cough treatment, offering a safe, effective, and rapid solution to alleviate the symptoms and address the underlying causes of dry and wet cough.


See full publication (PDF)


Main results

 

ANTIBIOTICS
Requirements for antibiotics strongly diminished in the test group (10.81 % patients) vs placebo group (82.35 %)

 

SEVERITY
15,81 % reduction in dry cough severity within 2 days.
32,08 % reduction in dry cough severity within 3 days.
46,39 % reduction in dry cough severity within 6 days.
62,65 % reduction in dry cough severity within 9 days.
76 % reduction in dry cough severity within 12 days.

 

FREQUENCY
50 % reduction in dry cough frequency within 6 days.
80 % reduction in dry cough frequency within 12 days.
98 % reduction in dry cough frequency within 14 days.

 

THROAT IRRITATION
7,5 % reduction in throat irritation within 2 hours.
40 % reduction in throat irritation within 3 days.
60 % reduction in throat irritation within 6 days.
80 % reduction in throat irritation within 9 days.
90 % reduction in throat irritation within 12 days.


Throat irritation lower by 37,8 % within 3 days compare to the placebo group.
Throat irritation lower by 55,4 % within 6 days compare to the placebo group.
Throat irritation lower by 73,4 % within 9 days compare to the placebo group.
Throat irritation lower by 89,7 % within 12 days compare to the placebo group.

 

THROAT PAIN
19 % reduction in throat pain within 2 days.
38 % reduction in throat pain within 3 days.

56 % reduction in throat pain within 6 days.
72 % reduction in throat pain within 9 days.
86 % reduction in throat pain within 12 days.
99 % reduction in throat pain within 14 days.




Product Details

  • Indication: Used in adults for the treatment of acute dry and wet cough.
  • Composition: Glycerol, Aqua, Honey, CDN-cyanidin (derived from the extracts of Hedera helix leaves and Curcuma longa roots), Eucalyptus globulus essential oil.
  • Presentation: Throat spray 30ml.
  • Class: MDR Class IIa.
  • Direction: Apply 4 sprays in the throat, 4 times a day.
  • Precautions: For topical use only (oral cavity). Keep out of reach and sight of children.
  • Exclusions: COUGHSPRAY should not be used without the advice of a doctor or pharmacist by patients taking medications known to cause cough as a side effect (e.g., ACE inhibitors or angiotensin II receptor blockers) or those diagnosed with conditions such as pneumonia, asthma, sinusitis, allergic rhinitis, heart disease, or chronic cough.
  • Age: Suitable for adults 18 and over.
  • Storage conditions: Below 25°C.
  • Legal manufacturer: VITROBIO (France).
  • Product code: CDN.