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NESOSPRAY : treatment for rhinosinusitis

NESOSPRAY  is an innovative nasal spray designed for the treatment of rhinosinusitis, rhinitis, and nasal congestion. It works by creating a filmogenic liquid bandage on the nasal mucosal surface, providing hydration, cleansing, and reducing contaminants and pro-inflammatory proteins through osmotic action. Clinical trials have shown a 34% reduction in nasal congestion within 30 minutes and a 48% reduction within 3 days. Other significant improvements were observed in headache and facial pain, with a 64% and 62% reduction respectively within 3 days. The quality of life of the patients also improved significantly.

Clinical trial

Randomized, double-blind, placebo-controlled trial


This product is intended for adult use


Treatment of sinusistis and rhinosinusitis (common cold)


Vitrobio presents NESOSPRAY, a novel solution specifically designed for the treatment of common cold, rhinosinusitis, rhinitis, and nasal congestion. This product is a nasal spray in a convenient 15 ml format, designed for easy application and optimal delivery of the active components.

Mode of action

Protective Barrier Effect

NESOSPRAY HE works by creating a filmogenic liquid bandage on the nasal mucosal surface. This protective barrier shields the nasal mucosa from further irritation or infection, providing an immediate layer of defense.

Osmotic Action

The spray also exerts an osmotic action, which attracts fluids towards the exterior, helping to massively unblock congested sinuses. This osmotic action also cleanses the nasal mucosa by effectively drawing out contaminants, debris, and pro-inflammatory proteins such as cytokines and interleukins. This dual action of unblocking and cleansing provides immediate relief and creates a clean environment conducive to healing.

Cellular Repair and Growth Effect

With the nasal mucosa now in a clean and protected state, the healing process can effectively begin. The spray promotes cell growth and repair, allowing the nasal mucosa to regenerate and regain its integrity. This restoration of the nasal mucosa is crucial for long-term relief from rhinosinusitis, rhinitis, and nasal congestion.

Clinical Trial

The effectiveness of NESOSPRAY HE has been evaluated in a randomized, double-blind clinical trial against a placebo, conducted over 3 weeks with 56 patients. The trial included patients with rhinosinusitis, encompassing all symptoms related to this condition.

The main results of the trial were highly promising. There was a 34% reduction in nasal congestion within 30 minutes.

Interestingly, the product initially increased nasal secretions (rhinorrhea) by 25% within 30 minutes of application due to its strong osmotic action. However, a 50% reduction in rhinorrhea was observed within a week, attributed to the healing and repair of the nasal mucosa.

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Main results


  • 34 % reduction in nasal congestion within 30 min​
  • 48 % reduction in nasal congestion within 3 days


  • 25% augmentation in rhinorrhea within 30 min (because the product strongly increases nasal secretions after application)​
  • 50% reduction in rhinorrhea with a week (due to the healing and repair of the mucosa)


  • 64% reduction in headache within 3 days​
  • 62% reduction in facial pain within 3 days​
  • Improvement of the quality of life

Product Details

  • Indication: Filmogen liquid bandage for the treatment of rhinosinusitis, rhinitis, and nasal congestion.
  • Composition: Filmogenic glycerol, HPC, water, EO: Mentha, Eucalypt, Thym, and Rosmar.
  • Presentation: Nasal spray 15ml.
  • Class: Current certification: MDD Class I | Certification in progress: MDR Class IIa.
  • Direction: Apply 2 sprays in each nostril, 2-3 times a day.
  • Precautions: For topical use only (nasal cavity). Keep out of reach and sight of children.
  • Age: 18+.
  • Storage conditions: Below 25°C.
  • Legal manufacturer: VITROBIO (France).
  • Product code: NHE.